Stromal cell-derived factor Gremlin 1 promotes tumour growth and metastasis of breast cancer.

基质细胞衍生因子 Gremlin 1 促进乳腺癌的肿瘤生长和转移。

• 批准号: nhmrc : GNT1160000
• 负责人: Dr Vasilios Panagopoulos
• 金额: $ 32.72万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stromal-cell-derived-breast-cancer/1349309
• 关键词: Stromal; cell; derived; factor; Gremlin

Breast cancer (BrCa) is the leading cause of cancer deaths in women worldwide. BrCa cells rely on features of the tumour microenvironment (TME) to grow and spread to distant sites. A heightened level of Grem1 is found within the TME of many cancers and is associated with increased tumour growth and blood vessel density. This study aims to identify the role of Grem1 in promoting BrCa growth and spread and identify Grem1 is a viable target as a new strategy for the urgent treatment of BrCa.

乳腺癌（BrCa）是全球女性癌症死亡的主要原因。BrCa细胞依赖于肿瘤微环境（TME）的特征生长并扩散到远处。在许多癌症的TME中发现Grem1水平升高，并与肿瘤生长和血管密度增加有关。本研究旨在确定Grem1在促进BrCa生长和扩散中的作用，并确定Grem1是一个可行的靶点，作为紧急治疗BrCa的新策略。