Structural Biology of Alzheimer's Disease

阿尔茨海默病的结构生物学

• 批准号: nhmrc : 1021935
• 负责人: Dr Luke Miles
• 金额: $ 36.99万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-biology-alzheimers-disease/110154
• 关键词: Structural; Biology; Alzheimer; Disease

It is estimated that one quarter of people over the age of 65 suffer from some form of memory impairment, mostly in the form of AlzheimerÍs disease. The enormous economic and social costs of the disease and an aging population make it a major health problem. This work will lead to atomic structures of proteins centrally involved in the disease, thus increasing our understanding of the molecular mechanisms of the disease and form the basis for the design of drugs to combat it.

据估计，65岁以上的人中有四分之一患有某种形式的记忆障碍，主要表现为阿尔茨海默病和S病。这种疾病造成的巨大经济和社会代价以及人口老龄化使其成为一个主要的健康问题。这项工作将导致与疾病密切相关的蛋白质的原子结构，从而增加我们对疾病分子机制的理解，并形成抗击疾病的药物设计的基础。