Structural and functional analysis of glucosyltransferases (Gtr) involved in O-antigen modification of Shigella flexneri

参与福氏志贺氏菌 O 抗原修饰的葡萄糖基转移酶 (Gtr) 的结构和功能分析

• 批准号: nhmrc : 1004846
• 负责人: A/Pr Naresh Verma
• 金额: $ 22.74万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-functional-analysis-shigella-flexneri/109073
• 关键词: Structural; functional; analysis; glucosyltransferases; Gtr

Shigellosis caused by Shigella flexneri is a medically significant disease in developing countries. Serotypes of S. flexneri are determined by bacterial cell-surface polysaccharides called O-antigens. Bacterial viruses carry the genes which confer O-antigen modification giving rise to different serotypes. The project will address fundamental processes related to the O-antigen modification by studying structure and function of the enzymes encoded by the O-antigen modification gene cluster.

由福氏志贺菌引起的志贺菌病是发展中国家的一种医学上重要的疾病。S.福氏杆菌是由称为O-抗原的细菌细胞表面多糖决定的。细菌病毒携带赋予O-抗原修饰的基因，从而产生不同的血清型。该项目将通过研究O-抗原修饰基因簇编码的酶的结构和功能来解决与O-抗原修饰相关的基本过程。