Structural and functional studies of T-cell mediated recognition of microbial lipids presented by CD1c

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The CD1c molecule plays an important role in the immune system by presenting lipid-based antigen of pathogens to the surface of an antigen presenting cell (APC) that is infected by the pathogen. Once a T cell receptor (TCR), which is expressed on the surface of a Killer T cell, recognises CD1c presenting pathogenic lipid, any infected cells will be destroyed. My research will look at the molecular mechanism of T cell recognising tuberculosis related lipids that is presented by CD1c.