Structural investigation of the Major Histocompatibility Complex class I peptide-loading complex

我们的免疫系统对病变细胞的识别和破坏对于控制感染的传播至关重要。这项建议的目的是肽加载复合物（PLC）的特性，一个大的分子机器，促进了“标记”感染细胞的过程中的关键步骤。确定其关键组件的3D结构以及它们相互作用的方式将有助于我们了解PLC如何有助于维持我们身体的健康。

The identification and destruction of diseased cells by our immune system is essential to controlling the spread of infection. This proposal is aimed at the characterisation of the peptide-loading complex (PLC), a large molecular machine that facilitates a crucial step in the process of ‘flagging’ infected cells. Determining the 3D structures of its key components, as well the way in which they interact will help us understand how the PLC contributes to maintaining our body’s health.