Structure and biophysical analysis aided design of novel toxoid vaccines for a major class of bacterial toxins.

灭活细菌毒素（类毒素），如破伤风疫苗，是安全有效的疫苗。胆固醇依赖性细胞溶素（cdc）是由许多重要的人类病原体产生的细菌毒素，包括A群链球菌（GAS）和肺炎球菌。肺炎链球菌没有可用的疫苗，肺炎球菌也没有通用疫苗。我们已经开发了一种新的灭活cdc的方法，这是基于它们如何靶向人类细胞的新知识，并将利用这些知识制造新的疫苗。

Inactivated bacterial toxins (toxoids), such as the tetanus vaccine, are safe and effective vaccines. Cholesterol dependent cytolysins (CDCs) are bacterial toxins produced by many important human pathogens including Group A Streptococcus (GAS) and Pneumococcus. GAS has no available vaccine and Pneumococcus does not have a universal vaccine. We have developed a new way of inactivating CDCs based on new knowledge of how they target human cells and will use this knowledge to make new vaccines.