Studies of the paracrine role of inhibin A/activin A in ovulation

抑制素 A/激活素 A 在排卵中的旁分泌作用研究

• 批准号: nhmrc : 211244
• 负责人: A/Pr Peter Illingworth
• 金额: $ 15.09万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-paracrine-role-aactivin-ovulation/97721
• 关键词: Studies; paracrine; role; inhibin; activin

This project aims to study the biochemical processes associated with normal egg maturation and release. Two mouse models will be used. One will involve culturing mouse ovarian tissue and inducing ovulation to study the processes. The other will involve study of gene expression in a mouse ovary around ovulation. The progressive accumulation of knowledge about the processes of ovulation will greatly improve our ability as doctors to manipulate ovulation in clinical practice. This will make an enormous difference to women s health in the following areas: contraception, the possibility of development of new methods of contraception that block egg release without affecting the normal ovarian cycle endocrinology; fertility treatment, better methods of obtaining mature oocytes without subjecting women to high dose gonadotrophin treatment and the accompanying sequelae; improving knowledge of the factors that promote satisfactory oocyte maturation and embryo development so that with improved implantation rates, fewer embryos need be replaced to achieve a pregnancy.

该项目旨在研究与正常卵子成熟和释放相关的生化过程。将使用两种小鼠模型。其中一个将涉及培养小鼠卵巢组织和诱导排卵来研究这一过程。另一个将涉及研究排卵期小鼠卵巢中的基因表达。关于排卵过程的知识的逐步积累将大大提高我们作为医生在临床实践中操纵排卵的能力。这将在以下领域对妇女的健康产生巨大影响：避孕，开发新的避孕方法的可能性，这种方法可以阻止卵子释放而不影响正常的卵巢周期内分泌学;生育治疗，获得成熟卵母细胞的更好方法，而不使妇女接受高剂量促性腺激素治疗和伴随的后遗症;提高对促进令人满意的卵母细胞成熟和胚胎发育的因素的认识，以便在提高植入率的情况下，更少的胚胎需要被替换以实现怀孕。