Studies of the paracrine role of inhibin A/activin A in ovulation

本项目旨在研究与正常卵子成熟和释放相关的生化过程。将使用两种鼠标模型。其中一项将涉及培养小鼠卵巢组织并诱导排卵来研究这一过程。另一项将涉及研究排卵前后小鼠卵巢中的基因表达。逐步积累有关排卵过程的知识将极大地提高我们作为医生在临床实践中操纵排卵的能力。这将在以下方面对女性S的健康产生巨大影响：避孕，开发新的避孕方法的可能性，在不影响正常卵巢周期内分泌的情况下阻止卵子释放；生育治疗，获得成熟卵母细胞的更好方法，而不使妇女接受高剂量促性腺激素治疗及其伴随的后遗症；增进对促进满意的卵母细胞成熟和胚胎发育因素的了解，以便随着着床率的提高，需要更换更少的胚胎即可怀孕。

This project aims to study the biochemical processes associated with normal egg maturation and release. Two mouse models will be used. One will involve culturing mouse ovarian tissue and inducing ovulation to study the processes. The other will involve study of gene expression in a mouse ovary around ovulation. The progressive accumulation of knowledge about the processes of ovulation will greatly improve our ability as doctors to manipulate ovulation in clinical practice. This will make an enormous difference to women s health in the following areas: contraception, the possibility of development of new methods of contraception that block egg release without affecting the normal ovarian cycle endocrinology; fertility treatment, better methods of obtaining mature oocytes without subjecting women to high dose gonadotrophin treatment and the accompanying sequelae; improving knowledge of the factors that promote satisfactory oocyte maturation and embryo development so that with improved implantation rates, fewer embryos need be replaced to achieve a pregnancy.