The Role of Androgens In Female Physiology

雄激素在女性生理学中的作用

• 批准号: nhmrc : 253775
• 负责人: A/Pr Peter Illingworth
• 金额: $ 25.26万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-androgens-female-physiology/83192
• 关键词: Role; Androgens; Female; Physiology

This study is aiming to develop an unique mouse model in which to study the question whether testosterone plays an essential role in female reproductive and general health. It will develop a genetic mouse model for a biological state of complete resistance to the effects of androgens. Such mice and humans are well known among genetic males but this cannot occur naturally among genetic female mammals. By creating such a mouse line, this project will be able to test for the first time indetail whether testosterone has an impotant role in the development and function of the ovary and of other female tissues such as bone, muscle and the brain.

这项研究旨在开发一种独特的小鼠模型，以研究睾酮是否在女性生殖和一般健康中起着重要作用。它将开发一种遗传小鼠模型，用于完全抵抗雄激素影响的生物状态。这样的小鼠和人类在遗传雄性中是众所周知的，但这在遗传雌性哺乳动物中不可能自然发生。通过建立这样一个小鼠系，该项目将能够第一次详细测试睾丸激素是否在卵巢和其他女性组织（如骨骼、肌肉和大脑）的发育和功能中起重要作用。