Subcellular trafficking of P proteins of human pathogenic viruses: roles in viral pathogenicity and targeting for therapeutics

为了感染人类，狂犬病、尼帕、亨德拉和澳大利亚蝙蝠溶血病毒等致病病毒必须能够逃避免疫反应。为了做到这一点，病毒产生“干扰素拮抗剂”，通过尚未完全了解的机制干扰特定的免疫过程。我们的研究将描述狂犬病和其他病毒用来阻断免疫的机制，并确定禁用病毒免疫逃避的策略，使这些致命的病毒容易被人类免疫系统破坏。

In order to infect humans, pathogenic viruses such as rabies, Nipah, Hendra and Australian bat lyssavirus must be able to evade the immune response. To do this, viruses produce "interferon antagonists" that interfere with specific immune processes by mechanisms that are not fully understood. Our study will characterise the mechanisms used by rabies and other viruses to block immunity, and identify strategies to disable viral immune evasion, rendering these lethal viruses susceptible to destruction by the human immune system.