Subcellular trafficking of P proteins of human pathogenic viruses: roles in viral pathogenicity and targeting for therapeutics

人类病原病毒 P 蛋白的亚细胞运输：在病毒致病性和治疗靶向中的作用

• 批准号: nhmrc : 1003244
• 负责人: Dr Gregory Moseley
• 金额: $ 38.56万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/subcellular-trafficking-p-targeting-therapeutics/108908
• 关键词: Subcellular; trafficking; proteins; human; pathogenic

In order to infect humans, pathogenic viruses such as rabies, Nipah, Hendra and Australian bat lyssavirus must be able to evade the immune response. To do this, viruses produce "interferon antagonists" that interfere with specific immune processes by mechanisms that are not fully understood. Our study will characterise the mechanisms used by rabies and other viruses to block immunity, and identify strategies to disable viral immune evasion, rendering these lethal viruses susceptible to destruction by the human immune system.

为了感染人类，狂犬病病毒、尼帕病毒、亨德拉病毒和澳大利亚蝙蝠狂犬病病毒等致病病毒必须能够逃避免疫反应。为此，病毒产生“干扰素拮抗剂”，通过尚未完全了解的机制干扰特定的免疫过程。我们的研究将阐明狂犬病和其他病毒阻断免疫的机制，并确定禁用病毒免疫逃避的策略，使这些致命病毒易于被人类免疫系统破坏。