Viral targeting of STAT proteins: roles in disease

病毒逃避宿主免疫反应的能力对疾病的发展至关重要。我们最近发现，特定的病毒蛋白与宿主免疫蛋白STATS的相互作用在由LyssaVirus引起的致死性疾病中至关重要。在这个项目中，我们的目标是详细地确定这些相互作用在病毒修饰宿主生物和逃避免疫反应中的功能，并利用这些信息来开发针对高致病性人类病毒的新疫苗。

The capacity of viruses to evade the host immune response is critical to the development of disease. We recently showed that interaction of specific viral proteins with host immune proteins called STATs is vital to lethal disease caused by lyssaviruses. In this project, we aim to define in detail the functions of these interactions in viral modification of host biology and evasion of the immune response, and to use this information to develop new vaccines against highly pathogenic human viruses.