Switching on Brain Transporters to Switch off Brain Seizures

打开大脑转运蛋白以关闭大脑癫痫发作

• 批准号: nhmrc : GNT1065882
• 负责人: A/Pr Andrew Moorhouse
• 金额: $ 34.58万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/switching-brain-transporters-brain-seizures/1344900
• 关键词: Switching; Brain; Transporters; Switch; off

Brain activity depends upon the fine balance between neuronal excitation and inhibition. When this balance is lost, debilitating seizures can result, such as occurs in epilepsy. We have developed a new gene manipulation approach to enhance neuronal inhibition and prevent seizures in mice. We will examine the physiological mechanisms underlying this effect, and we propose that we can also use this genetic switch to stop the progression into epilepsy that occurs following a brain trauma.

大脑活动取决于神经元兴奋和抑制之间的微妙平衡。当这种平衡失去时，会导致虚弱的癫痫发作，如癫痫发作。我们已经开发了一种新的基因操作方法来增强小鼠神经元抑制和预防癫痫发作。我们将研究这种效应背后的生理机制，我们建议我们也可以使用这种遗传开关来阻止脑外伤后发生的癫痫进展。