Instrument for characterization of plymers and solute release kinetics

用于表征聚合物和溶质释放动力学的仪器

• 批准号: 374799-2009
• 负责人: Wu, XiaoYu(Shirley)
• 金额: $ 5.51万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=412017
• 关键词: Instrument; characterization; plymers; solute; release

Biocompatible polymers have been widely used to make various advanced medications such as once daily blood-pressure-controlling pills that provide more effective treatment with lower side effects than conventional medications. The properties of polymers such as molecular weight and dissolving rate determine when and how fast the medicine will take effect thus affecting the therapeutic benefit of such medications. Unlike small molecules, polymers prepared in one reaction can have different molecular weights, and some polymers degrade during application thus controlling the release rate of therapeutic agents from the medications.

生物相容性聚合物已被广泛用于制造各种先进的药物，如每天一次的血压控制药丸，提供比传统药物更有效的治疗和更低的副作用。聚合物的性质，如分子量和溶解速率，决定了药物何时以及多快起效，从而影响这些药物的治疗效果。与小分子不同，在一个反应中制备的聚合物可以具有不同的分子量，并且一些聚合物在应用期间降解，从而控制治疗剂从药物中的释放速率。