Targeted inhibition of Multidrug Resistance-associated Protein 4 (MRP4) as a therapeutic strategy for childhood neuroblastoma

点击翻译按钮获取中文摘要

We have shown that a high tumour level of the gene, MRP4, confers a particularly poor outcome in children with the aggressive cancer neuroblastoma. Our results suggest that MRP4 can drive the growth of neuroblastoma cells, and that it does so by removing from the cancer cell a compound that normally regulates key cellular responses including survival and differentiation. We will explore this, and will also test promising inhibitors of MRP4 with therapeutic potential, that we have developed.