Identification of new therapeutic targets in neuroblastoma through ABCC transporter associated pathways.

通过 ABCC 转运蛋白相关途径鉴定神经母细胞瘤的新治疗靶点。

• 批准号: nhmrc : 630608
• 负责人: Dr Jamie Fletcher
• 金额: $ 39.44万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-new-therapeutic-associated-pathways/96796
• 关键词: Identification; new; therapeutic; targets; neuroblastoma

Neuroblastoma accounts for 15% of childhood cancer deaths. Children diagnosed over 1 year have survival rates below 40%. New research shows that certain genes previously implicated in drug resistance contribute to neuroblastoma development. We will investigate their role using a new neuroblastoma model and a range of biochemical and cell biology techniques. This research will improve our understanding of neuroblastoma biology and identify new therapeutic targets in this and other cancers.

神经母细胞瘤占儿童癌症死亡的15%。确诊1年以上的儿童存活率低于40%。新的研究表明，以前与耐药性有关的某些基因有助于神经母细胞瘤的发展。我们将使用一种新的神经母细胞瘤模型和一系列生物化学和细胞生物学技术来研究它们的作用。这项研究将提高我们对神经母细胞瘤生物学的理解，并确定这种癌症和其他癌症的新治疗靶点。