Identification of new therapeutic targets in neuroblastoma through ABCC transporter associated pathways.

神经母细胞瘤占儿童癌症死亡的15%。确诊超过1年的儿童存活率低于40%。新的研究表明，某些先前与耐药性有关的基因有助于神经母细胞瘤的发展。我们将使用新的神经母细胞瘤模型和一系列生化和细胞生物学技术来研究它们的作用。这项研究将提高我们对神经母细胞瘤生物学的理解，并确定这种癌症和其他癌症的新治疗靶点。

Neuroblastoma accounts for 15% of childhood cancer deaths. Children diagnosed over 1 year have survival rates below 40%. New research shows that certain genes previously implicated in drug resistance contribute to neuroblastoma development. We will investigate their role using a new neuroblastoma model and a range of biochemical and cell biology techniques. This research will improve our understanding of neuroblastoma biology and identify new therapeutic targets in this and other cancers.