Targeted therapy in APC deleted colon cancers

APC 缺失结肠癌的靶向治疗

• 批准号: nhmrc : GNT1140808
• 负责人: A/Pr Joseph Rosenbluh
• 金额: $ 53.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeted-therapy-apc-colon-cancers/1348330
• 关键词: Targeted; therapy; APC; deleted; colon

Despite the high mortality associated with colon cancer only limited therapy options are available to treat these cancers. Here we propose a new strategy for inhibiting colon cancers driven by a specific type of mutations. Our preliminary data show that loss of DNA encoding a tumor suppressor gene creates a unique vulnerability in colon cancers. The aim of this proposal is to exploit this vulnerability as a strategy for combating colon cancer.

尽管结肠癌的死亡率很高，但治疗这些癌症的选择有限。在这里，我们提出了一种新的策略，以抑制由特定类型的突变驱动的结肠癌。我们的初步数据显示，编码肿瘤抑制基因的DNA丢失在结肠癌中造成了一种独特的脆弱性。这项提议的目的是利用这种脆弱性作为对抗结肠癌的一种策略。