Targeting the AGE-RAGE axis in diabetes associated atherosclerosis

靶向糖尿病相关动脉粥样硬化中的 AGE-RAGE 轴

• 批准号: nhmrc : 586676
• 负责人: Prof Angelika Bierhaus
• 金额: $ 36.2万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-age-rage-associated-atherosclerosis/77583
• 关键词: Targeting; AGE; RAGE; axis; diabetes

Based on extensive preliminary data we porpose that the AGE intercation with RAGE plays an important role in diabetes associated atherosclerosis. We will perform studies using a soluble form of the receptor RAGE which will trap AGEs in the blood and tissues and thus prevent diabetes related blood vessel damage. Furthermore, we will investigate if RAGE receptor on inflammatory cells such as macrophages plays a pivotal role in blood vessel injury in diabetes.

基于大量的初步数据，我们认为AGE与RAGE的相互作用在糖尿病相关的动脉粥样硬化中发挥着重要作用。我们将使用可溶性形式的受体β进行研究，该受体β将捕获血液和组织中的AGEs，从而防止糖尿病相关的血管损伤。此外，我们将研究炎症细胞如巨噬细胞上的β受体是否在糖尿病血管损伤中起关键作用。