Targeting the AGE-RAGE axis in diabetes associated atherosclerosis

基于大量的初步数据，我们认为年龄与RAGE的相互作用在糖尿病相关动脉粥样硬化中起着重要作用。我们将使用受体RAGE的一种可溶形式进行研究，这种受体将捕获血液和组织中的AGEs，从而防止糖尿病相关的血管损伤。此外，我们将研究巨噬细胞等炎性细胞上的RAGE受体是否在糖尿病血管损伤中发挥关键作用。

Based on extensive preliminary data we porpose that the AGE intercation with RAGE plays an important role in diabetes associated atherosclerosis. We will perform studies using a soluble form of the receptor RAGE which will trap AGEs in the blood and tissues and thus prevent diabetes related blood vessel damage. Furthermore, we will investigate if RAGE receptor on inflammatory cells such as macrophages plays a pivotal role in blood vessel injury in diabetes.