Mediation pathways for the receptor for advanced glycation end products in diabetic nephropathy

糖尿病肾病晚期糖基化终末产物受体的介导途径

• 批准号: nhmrc : 367602
• 负责人: Prof Angelika Bierhaus
• 金额: $ 22.26万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mediation-pathways-receptor-diabetic-nephropathy/100349
• 关键词: Mediation; pathways; receptor; advanced; glycation

Excess sugar in the blood from diabetes is detrimental and can accelerate a process where sugar attaches itself to proteins, fats and DNA. Although facilitated by high sugar, the reaction occurs happily in the presence of low sugar with high levels of free oxygen radicals. These complexes are called advanced glycation end products or AGEs. In addition, we ingest vast volumes of AGES from our diet which are taken into the blood. These AGEs are known to be involved in the development of kidney disease in diabetic subjects. AGEs exert most of their effects on the body by binding to specific proteins, the most common and nasty of which is the receptor for advanced glycation end products, RAGE. RAGE is a known participant in other serious diseases such as Alzheimer's disease and evidence is mounting for its central role in the development of kidney disease in diabetic subjects. There is not much known about the processes which mediate RAGE which is why this is the aim of this proposal. This will enable us to stop the relentless progression of kidney disease in diabetes.

糖尿病血液中过量的糖是有害的，可以加速糖与蛋白质、脂肪和DNA结合的过程。虽然高糖促进了反应，但在低糖和高水平的氧自由基存在下，反应愉快地发生。这些复合物被称为晚期糖基化终产物或AGEs。此外，我们从饮食中摄入大量的AGES，这些AGES被带入血液。已知这些AGEs参与糖尿病受试者肾脏疾病的发展。AGEs通过与特定的蛋白质结合来发挥它们对身体的大部分作用，其中最常见和最讨厌的是晚期糖基化终末产物的受体。众所周知，糖尿病是其他严重疾病（如阿尔茨海默病）的参与者，并且越来越多的证据表明其在糖尿病受试者肾脏疾病的发展中起着核心作用。目前对介导这一过程的了解不多，这就是为什么这是本提案的目的。这将使我们能够阻止糖尿病肾病的无情进展。