Targeting cell survival pathways in cancer

靶向癌症中的细胞存活途径

• 批准号: nhmrc : GNT1064211
• 负责人: Dr Mark Guthridge
• 金额: $ 60.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-cell-survival-pathways-cancer/1344864
• 关键词: Targeting; cell; survival; pathways; cancer

While most leukemia patients initially respond well to chemotherapy, >70% die because the disease returns as a result of the survival of leukaemia cells following treatment. We seek to block the switch mechanisms within leukemic cells that allow them to survive current drug therapies. We now seek to examine the therapeutic potential of our discovery with a view toward developing new targetted therapies in the future.

虽然大多数白血病患者最初对化疗反应良好，但超过 70% 的患者会死亡，因为治疗后白血病细胞的存活导致疾病复发。我们试图阻断白血病细胞内的开关机制，使它们能够在当前的药物治疗中存活下来。我们现在寻求检查我们发现的治疗潜力，以期在未来开发新的靶向疗法。