The regulation of pleiotropic responses by bidentate motifs embedded in the Fibroblast Growth Factor Receptors

成纤维细胞生长因子受体中嵌入的双齿基序对多效性反应的调节

• 批准号: nhmrc : 626976
• 负责人: Dr Mark Guthridge
• 金额: $ 32.63万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-pleiotropic-responses-factor-receptors/98441
• 关键词: regulation; pleiotropic; responses; bidentate; motifs

Cells in our bodies are able to accomplish an impressive array of functions. Diffusible factors (called growth factors) are important in regulating diverse cellular functions. We have identified a new molecular switch inside cells that acts as a master controller of cellular functions. This molecular switch relays information to instruct specific cellular functions. We have shown that these molecular switches are short-circuited in breast cancer promoting cell growth and survival.

我们体内的细胞能够完成一系列令人印象深刻的功能。扩散因子（称为生长因子）在调节多种细胞功能中很重要。我们已经确定了一个新的细胞内的分子开关，作为细胞功能的主控制器。这种分子开关传递信息以指示特定的细胞功能。我们已经证明，这些分子开关在乳腺癌中短路，促进细胞生长和存活。