Targeting the class IIa histone deacetylases in metabolic disease

靶向代谢疾病中的 IIa 类组蛋白脱乙酰酶

• 批准号: nhmrc : 1030474
• 负责人: A/Pr Sean Mcgee
• 金额: $ 27.23万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-class-iia-metabolic-disease/110758
• 关键词: Targeting; class; IIa; histone; deacetylases

Dysfunctional metabolism in skeletal muscle is integral in the development of metabolic diseases, such as obesity and type 2 diabetes. This project will examine proteins that alter the way genes are expressed for their role in dysfunctional metabolism in muscle. This project could uncover new therapies for the treatment of metabolic diseases.

骨骼肌代谢功能障碍是代谢性疾病发展过程中不可或缺的一环，如肥胖和2型糖尿病。这个项目将研究改变基因表达方式的蛋白质，以确定它们在肌肉功能失调的新陈代谢中的作用。该项目可能会发现治疗代谢性疾病的新疗法。