Targeting critical nodes on the IGF1-PI3K pathway to improve function of the failing heart

针对 IGF1-PI3K 通路上的关键节点来改善衰竭心脏的功能

• 批准号: nhmrc : 526647
• 负责人: A/Pr Elizabeth Woodcock
• 金额: $ 34.2万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-critical-nodes-failing-heart/94920
• 关键词: Targeting; critical; nodes; IGF1; PI3K

Heart failure is a major clinical problem which is becoming worse as our population grows older and comorbidities such as obesity and diabetes become more prevalent. Current heart failure therapeutics largely delay disease progression. This research proposal focuses on strategies designed to improve function of the failing heart, as opposed to simply delaying disease progression. This approach will lead to the development of new therapeutics.

心力衰竭是一个主要的临床问题，随着我们人口的老龄化和肥胖和糖尿病等合并症的流行，心力衰竭变得越来越严重。目前的心力衰竭治疗在很大程度上延缓了疾病进展。这项研究计划的重点是旨在改善衰竭心脏功能的策略，而不是简单地延缓疾病进展。这种方法将导致新疗法的发展。