Regulation of cardiac hypertrophy a at the level of ribosome biogenesis

核糖体生物发生水平上心脏肥大的调节

• 批准号: nhmrc : 508907
• 负责人: A/Pr Elizabeth Woodcock
• 金额: $ 42.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-cardiac-hypertrophy-ribosome-biogenesis/95395
• 关键词: Regulation; cardiac; hypertrophy; level; ribosome

A major feature of cardiac hypertrophy (enlarged heart) is accelerated cell growth and protein synthesis. This results from increased synthesis of ribosomes (the protein synthetic machinery). This study will examine a factor termed UBF whose activity is critical for the regulation of ribosome synthesis. Understanding the mechanisms controlling UBF function will provide new avenues in which to develop therapeutics to combat hypertrophic heart disease.

心肌肥大(心脏增大)的一个主要特征是细胞生长和蛋白质合成加速。这是核糖体(蛋白质合成机械)合成增加的结果。这项研究将检测一种被称为UBF的因子，其活性对调节核糖体合成至关重要。了解UBF功能的控制机制将为开发治疗肥厚性心脏病的方法提供新的途径。