Targeting G-quadruplex DNA as a novel therapeutic strategy for Alzheimer’s and Frontotemporal Dementia

靶向 G-四链体 DNA 作为阿尔茨海默病和额颞叶痴呆的新型治疗策略

• 批准号: nhmrc : GNT1139936
• 负责人: Dr Nicole Smith
• 金额: $ 72.01万
• 依托单位国家: 澳大利亚
• 项目类别: Boosting Dementia Research Initiative
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-g-quadruplex-frontotemporal-dementia/1348270
• 关键词: Targeting; quadruplex; DNA; novel; therapeutic

Dementia is the third leading cause of death in Australia and there is an urgent need to identify new ways of treating diseases that cause dementia. Our research is focused on targeting an unusual DNA structure in Alzheimer’s and Frontotemporal dementia (FTD). We will use a precision-targeted technology to better control formation of this DNA structure in disease-causing genes, allowing us to switch off the gene and hence stop disease progression for Alzheimer’s and FTD.

痴呆症是澳大利亚第三大死亡原因，迫切需要找到治疗导致痴呆症的疾病的新方法。我们的研究重点是针对阿尔茨海默病和额颞叶痴呆 (FTD) 中不寻常的 DNA 结构。我们将使用精确靶向技术来更好地控制致病基因中这种 DNA 结构的形成，从而使我们能够关闭该基因，从而阻止阿尔茨海默病和 FTD 的疾病进展。