Targeting HCK in Pancreatic Ductal Adenocarcinoma to Restrict Tumour Growth and Metastasis

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This project will define the therapeutic benefit of targeting a protein known as Haematopoietic Cell Kinase (HCK) in pancreatic ductal adenocarcinoma. Increased HCK activity promotes tumour growth by facilitating the polarisation of macrophages towards an alternatively activated “tumourigenic” endotype, which are a major component of pancreatic tumours. We hypothesise that the therapeutic targeting of HCK will reduce pancreatic tumour growth by impairing alternative macrophage polarisation.