Targeting insulin hypersecretion to prevent type 1 and type 2 diabetes

针对胰岛素分泌过多预防 1 型和 2 型糖尿病

• 批准号: nhmrc : 1128442
• 负责人: Prof Christopher Nolan
• 金额: $ 57.03万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-insulin-hypersecretion-2-diabetes/948220
• 关键词: Targeting; insulin; hypersecretion; prevent; type

Diabetes develops when islet beta-cells fail to secrete insulin. While major differences exist in the mechanisms by which type 1 and type 2 diabetes develop, there is overlap in beta-cell susceptibility factors. We will investigate whether an islet 'overwork' response to excess nutrient loads underlies beta-cell susceptibility to failure in both types of diabetes. We will also develop novel pharmacological approaches to reduce islet 'overwork' to prevent and treat type 1 and 2 diabetes.

当胰岛β细胞不能分泌胰岛素时，就会发生糖尿病。虽然1型和2型糖尿病发展的机制存在重大差异，但β细胞易感因子存在重叠。我们将研究胰岛对过量营养负荷的“过度工作”反应是否是两种类型糖尿病中β细胞易感性失败的基础。我们还将开发新的药理学方法来减少胰岛“过度工作”，以预防和治疗1型和2型糖尿病。