Role of islet ?-cell failure in the pathogenesis of non-alcoholic steatohepatitis

胰岛β细胞衰竭在非酒精性脂肪性肝炎发病机制中的作用

• 批准号: nhmrc : 1028108
• 负责人: Prof Christopher Nolan
• 金额: $ 37.35万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-islet-cell-alcoholic-steatohepatitis/110614
• 关键词: Role; islet; cell; failure; pathogenesis

Some people respond to obesity poorly developing diseases such as non-alcoholic steatohepatitis (NASH) and diabetes. Other people do not, safely storing the excess energy in non-abdominal fat. The applicants will study 2 obese strains of mice; one develops “adipose tissue restriction”, NASH and diabetes, the other does not. The hypothesis that failure of compensatory insulin secretion to over-nutrition is an upstream event causing adipose tissue restriction, followed by NASH, will be tested.

有些人对肥胖反应不佳，发展为非酒精性脂肪性肝炎（NASH）和糖尿病等疾病。其他人不这样做，将多余的能量安全地储存在非腹部脂肪中。申请者将研究2种肥胖小鼠；一个会发展成“脂肪组织限制”、NASH和糖尿病，另一个则不会。代偿性胰岛素分泌失败导致营养过剩是导致脂肪组织受限的上游事件，随后是NASH，这一假设将被验证。