Targeting iron piracy from host proteins by Neisseria and Haemophilus spp. for the development of novel antimicrobials

针对奈瑟菌属和嗜血杆菌属宿主蛋白的铁盗版行为。

• 批准号: nhmrc : 1197376
• 金额: $ 64.52万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-iron-piracy-novel-antimicrobials/1779303
• 关键词: Targeting; iron; piracy; host; proteins

The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.

引起性传播感染、淋病和脑膜炎双球菌疾病的细菌是一个严重的健康问题。为了致病，这些细菌必须从我们的身体中获取营养铁。这项拟议的研究将使用尖端技术在分子水平上了解这些细菌如何在感染期间获得铁。然后，它将应用这些知识来开发阻止这些细菌获得铁的分子，作为治疗这些疾病的一种手段。