Synthetic chemistry based on Rh(II)-carbenoid reactions and synthesis of alkaloids

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There is an increasing demand for organic molecules with diverse structural features and functionality for use in the manufacturing of new materials, in the discovery of new medicines and in the chemical industry for the manufacture of fine chemicals. Novel bioactive molecules are also useful as "tools" for studying and understanding biochemical processes, which would have important implications in the advancement of medical research. Some of the molecules are not made by nature and others that occur in nature are only available in small amounts. Extracting such compounds from nature can have negative impacts on our environment and the ecosystem. Organic synthesis provides a way for making these molecules available and in sufficient quantities so that studies on their (bio)chemical and physical properties can be conducted. The proposed research is concerned with the design, study and development of new methods and catalysts for making of new compounds from simple organic building blocks. The ultimate goal in these studies is to develop practical methods that can be used for the synthesis of medicinally important, biologically active compounds. New drugs, such as anticancer, antihypertensive and anti-inflammatory drugs, can benefit health of society. The results from the proposed studies will contribute to the knowledge base in the chemical sciences and to the advancement in chemical synthesis. The latter plays a vital role in the chemical and pharmaceutical manufacturing sectors in Canada and hence the economy of Canada. Another important aspect of my research program is the training of graduates and undergraduates in the methodology of scientific inquiry and research, which helps ensure that Canada has the technological edge to compete in the global economy.