Targeting of the Myb-p300 Interaction in Myeloid Leukaemogenesis

髓系白血病发生中 Myb-p300 相互作用的靶向

• 批准号: nhmrc : 1023175
• 负责人: A/Pr Mark Smythe
• 金额: $ 41.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-myb-p300-myeloid-leukaemogenesis/110250
• 关键词: Targeting; Myb; p300; Interaction; Myeloid

MYB is a “cancer gene” which turns other genes on or off. MYB is needed by leukaemia cells but also for normal blood cell formation. This project aims to show that blocking interaction between the MYB protein and another protein called p300 is a promising strategy for leukaemia treatment, as leukaemia cells are more dependent on this interaction than normal cells. New molecules to block the MYB-p300 interaction will also be designed and tested; these may form a basis for new leukaemia drugs.

MYB是一种“癌症基因”，它可以打开或关闭其他基因。MYB是白血病细胞所需要的，但也是正常血细胞形成所需要的。该项目旨在表明，阻断MYB蛋白与另一种称为p300的蛋白质之间的相互作用是一种有希望的白血病治疗策略，因为白血病细胞比正常细胞更依赖于这种相互作用。还将设计和测试阻断MYB-p300相互作用的新分子;这些可能成为新的白血病药物的基础。