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Targeting the Oncoprotein MDMX as a Novel Treatment for Triple Negative Breast Cancer

Targeting the Oncoprotein MDMX as a Novel Treatment for Triple Negative Breast Cancer
靶向癌蛋白 MDMX 作为三阴性乳腺癌的新型治疗方法
批准号：
nhmrc : GNT1123057
负责人：
A/Pr Elgene Lim
金额：
$56.17万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2017
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2017-01-01 至 --
来源：
https://researchdata.edu.au/targeting-oncoprotein-mdmx-breast-cancer/1347320
关键词：
TargetingOncoproteinMDMXNovelTreatment

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英文摘要
Breast cancer (BrCa) is a leading cause of cancer death in women worldwide. BrCas unable to respond to current therapies have the worst outcomes. We propose a novel strategy to treat these cancers, based on our new findings. Our two protein targets are: (1) MDMX, that we found drives BrCa with its partner, (2) mutant p53, which causes cancer spread. We plan to directly target these drivers of aggressive BrCas, using new drugs that individually show great promise in trials in a number of cance
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