Targeting Plasmodium falciparum Gametocytes

靶向恶性疟原虫配子细胞

• 批准号: nhmrc : 1038675
• 负责人: Miss Alice Butterworth
• 金额: $ 5.43万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-plasmodium-falciparum-gametocytes/111199
• 关键词: Targeting; Plasmodium; falciparum; Gametocytes

The transmission of malaria is dependent on gametocytes, the sexual stages of parasite development that are taken up by mosquitoes when feeding on an infected person. While gametocytes are not responsible for disease symptoms, it is clear that malaria eradication is not be possible without an understanding of their biology and the tools to prevent transmission. My research focuses on understanding the biology of gametocytes and identifying new drug targets for transmission blocking strategies.

疟疾的传播依赖于配子体，配子体是寄生虫发育的有性阶段，蚊子在以感染者为食时将其吸收。虽然配子体与疾病症状无关，但很明显，如果不了解配子体的生物学和预防传播的工具，根除疟疾是不可能的。我的研究重点是了解配子体的生物学和识别新的药物靶点的传输阻断策略。