Endocrine conttrol of gestation in mammals: structural and functional characterization of a novel steroid, estradioenolone (ED)

维持妊娠的细胞机制还不是很清楚。我们已经确定了一种名为ED的新型类固醇激素，它可能在妊娠维持中发挥重要作用。我们建议更多地了解这种荷尔蒙是如何作用的。由于ED和其他激素一样，只存在于血液和尿液中的少量，所以化学合成ED很重要，这样大量的ED就可以用于各种实验。我们建议研究ED如何影响胎儿、胎盘和控制妊娠。从这些研究中获得的知识可能会为减少动物和人类早孕损失和更好地管理怀孕的新发现开辟道路。

The cellular mechanisms involved in the maintenance of pregnancy are not well understood. We have identified a novel steroid hormone called ED, which may play an important role in pregnancy maintenance. We propose to learn more about how this hormone acts. Since ED, like other hormones are present only in small quantities in blood and urine, it is important to chemically synthesize ED so that large amounts are available for a wide variety of experiments. We propose to study how ED affects the fetus, placenta and control pregnancy. Knowledge gained from these studies may open ways to new discoveries for reducing early pregnancy losses and better management of pregnancy in animals and humans.