Endocrine conttrol of gestation in mammals: structural and functional characterization of a novel steroid, estradioenolone (ED)

哺乳动物妊娠的内分泌控制：新型类固醇雌二烯醇酮 (ED) 的结构和功能表征

• 批准号: 138634-2007
• 负责人: Philip, Anie
• 金额: $ 2.08万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=451868
• 关键词: Endocrine; conttrol; gestation; mammals; structural

The cellular mechanisms involved in the maintenance of pregnancy are not well understood. We have identified a novel steroid hormone called ED, which may play an important role in pregnancy maintenance. We propose to learn more about how this hormone acts. Since ED, like other hormones are present only in small quantities in blood and urine, it is important to chemically synthesize ED so that large amounts are available for a wide variety of experiments. We propose to study how ED affects the fetus, placenta and control pregnancy. Knowledge gained from these studies may open ways to new discoveries for reducing early pregnancy losses and better management of pregnancy in animals and humans.

维持妊娠的细胞机制尚未完全了解。我们已经确定了一种新的类固醇激素称为艾德，这可能在妊娠维持中发挥重要作用。我们建议更多地了解这种激素的作用。由于艾德和其他激素一样，在血液和尿液中仅以少量存在，因此化学合成艾德非常重要，以便大量用于各种实验。我们拟研究艾德如何影响胎儿、胎盘和控制妊娠。 从这些研究中获得的知识可能会为减少动物和人类早期妊娠损失和更好地管理妊娠开辟新的发现。