Neuroprotective mechanisms of natural molecules against oxidative stress and apoptosis

天然分子对抗氧化应激和细胞凋亡的神经保护机制

• 批准号: 170571-2009
• 负责人: Martinoli, MariaGrazia
• 金额: $ 2.7万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=422794
• 关键词: Neuroprotective; mechanisms; natural; molecules; against

Our main research program focuses on the cellular mechanisms underlying neuronal damage in neurodegenerative disorders such as Parkinson's disease. We are analyzing the role of some oxidative and inflammatory agents in cellular degeneration and mortality. In this context, we are also interested in neuroprotective cellular mechanisms, i.e. the possibility that some steroids, particularly phytoestrogens and phytosterols, may act as anti-oxidative and/or anti-inflammatory molecules.

我们的主要研究项目集中在帕金森氏病等神经退行性疾病中潜在的神经元损伤的细胞机制。我们正在分析一些氧化和炎症因子在细胞退化和死亡中的作用。在这种背景下，我们还对神经保护的细胞机制感兴趣，即一些类固醇，特别是植物雌激素和植物甾醇，可能作为抗氧化和/或抗炎分子。