Cellular Mechanisms Implicated in the Action of Neuroprotective Nutraceuticals

神经保护保健品作用中涉及的细胞机制

• 批准号: RGPIN-2015-04321
• 负责人: Martinoli, MariaGrazia
• 金额: $ 2.77万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629439
• 关键词: Cellular; Mechanisms; Implicated; Action; Neuroprotective

My research program aims to elucidate the cellular mechanisms and pathways implicated in the action of neuroprotective nutraceuticals, specifically plant-derived molecules (phytochemicals). Nutraceuticals are products that range from isolated nutrients, dietary supplements and herbal molecules possessing beneficial physiological properties. An abundant amount of literature is currently proposing a positive effect for these natural molecules in human and animal health. However, in most cases, their alleged pleiotropic beneficial effects have not yet been accurately documented. In this context, my laboratory analyses the role of several phytochemicals in opposing neurodegeneration and neuroinflammation induced by neurotoxins or high glucose administration, in established cellular paradigms and animal models. We are specifically interested in defining the specific cellular mechanisms and pathways used by neuroprotective and anti-inflammatory phytochemicals. Recently, we demonstrated that plant derived molecules such as quercetin, cucurbitacins and sesamin possess multiple cellular properties that go beyond their anti-oxidation action generally known, but also extend to the reduction of both apoptosis and neuroinflammation. Based on our knowledge of natural compounds, for the next five years, I propose to elucidate the cellular mechanisms and pathways implicated in the action of neuroprotective phytochemicals. For this we will focus on three specific aims:

我的研究项目旨在阐明神经保护性营养品，特别是植物源性分子（植物化学物质）的作用所涉及的细胞机制和途径。营养保健品是具有有益生理特性的产品，包括分离的营养素、膳食补充剂和草药分子。大量的文献目前提出了这些天然分子对人类和动物健康的积极影响。然而，在大多数情况下，其所谓的多效性有益作用尚未得到准确的记录。在这种情况下，我的实验室分析了几种植物化学物质在对抗神经毒素或高葡萄糖管理诱导的神经变性和神经炎症中的作用，在建立的细胞范例和动物模型中。我们特别感兴趣的是确定神经保护和抗炎植物化学物质所使用的特定细胞机制和途径。最近，我们证明了植物衍生的分子，如槲皮素，葫芦素和芝麻素具有多种细胞特性，超出了他们的抗氧化作用一般已知的，但也扩展到减少细胞凋亡和神经炎症。基于我们对天然化合物的了解，在接下来的五年里，我建议阐明神经保护植物化学物质作用中所涉及的细胞机制和途径。为此，我们将重点关注三个具体目标：