The bacterial type IX secretion system in polymicrobial dysbiosis and chronic inflammation

牙周炎(严重的牙周病)影响三分之一的成年人，并与心脏病发作、癌症和痴呆症有关。我将领导一个多学科的团队，调查口腔中的致病细菌与免疫反应之间的相互作用，免疫反应会破坏牙齿的支持组织，并使细菌进入血液。预期的结果是开发一种新的治疗方法，阻止与这些病原体相关的疾病的发展。

Periodontitis (severe gum disease) affects 1 in 3 adults and has been linked with heart attacks, cancer and dementia. I will lead a multidisciplinary team investigating the interaction between disease causing bacteria in the mouth and the immune response which results in destruction of the tooth’s supporting tissues and allows bacteria to enter the blood stream. The expected outcome is the development of a novel therapy which will stop progression of disease associated with these pathogens.