Structural Characterisation of the Type IX Secretion System

IX 型分泌系统的结构表征

• 批准号: DP200100914
• 负责人: Prof Eric Reynolds
• 金额: $ 41.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100914
• 关键词: Structural; Characterisation; Type; IX; Secretion

The Type IX Secretion System present in diverse bacteria of veterinary, agricultural, environmental and industrial importance enables effector proteins to be secreted and attached to the cell surface where they contribute to disease pathogenesis or degrade biopolymers of commercial interest. This project aims to determine the structure and assembly mechanism of this complex secretion nanomachine comprising 15 different proteins using state of the art microscopy. Knowledge of the structure will greatly enhance our understanding of secretion mechanisms and our ability to both inhibit the system to treat disease in animals or manipulate the system for industrial applications providing future economic and environmental benefits to our nation.

在兽医、农业、环境和工业上具有重要意义的各种细菌中存在的IX型分泌系统使效应蛋白能够分泌并附着在细胞表面，在那里它们有助于疾病的发病或降解具有商业价值的生物聚合物。该项目旨在利用最先进的显微镜来确定这种复杂的分泌纳米机器的结构和组装机制，该机器由15种不同的蛋白质组成。对该结构的了解将极大地提高我们对分泌机制的理解，以及我们抑制该系统治疗动物疾病或操纵该系统用于工业应用的能力，从而为我们的国家带来未来的经济和环境效益。