THE IMMUNOLOGICAL LEGACY OF OBESITY ON VIRAL PATHOGENESIS
THE IMMUNOLOGICAL LEGACY OF OBESITY ON VIRAL PATHOGENESIS
肥胖对病毒发病机制的免疫学影响
批准号：
nhmrc : 2003959
负责人：
金额：
$65.23万
依托单位国家：
澳大利亚
项目类别：
Ideas Grants
财政年份：
2021
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2021-01-01 至 2023-12-31
中文摘要
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英文摘要
Obesity is a key risk factor for severe viral infections. Our preliminary data suggest that in mice this susceptibility is not reduced by weight loss. In this grant we will investigate a) the mechanisms driving the legacy effect of obesity on antiviral immunity b) whether or not we can reverse this legacy effect by treatment with the drug MCC950 and c) the antiviral response of overweight children and adults who have and haven't recently lost weight.
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