The interactive effects of dietary saturated fat and apolipoprotein-E genotype on peripheral metabolism of lipoprotein-amyloid and neurovascular integrity.

这个项目是基于一个显着的发现，这表明，在一些人，阿尔茨海默病可能是腐败的微观血管，供应大脑，损坏的结果，过度暴露于血液中的蛋白质主要在肝脏产生的结果损坏。该项目将在阿尔茨海默病风险较高的受试者和人性化动物模型中进一步探索这一途径。这些发现可能为预防和治疗提供新的机会。

This project is based on a remarkable discovery which suggests that in some individuals, Alzheimer's disease may be a consequence of corruption of microscopic blood vessels that supply brain, damaged as a consequence of exaggerated exposure in blood to a protein produced principally in liver. The project will explore this pathway further in subjects at heightened risk of Alzheimer's disease and in humanised animal models. The findings may provide new opportunities for prevention and treatment.