The interactive effects of dietary saturated fat and apolipoprotein-E genotype on peripheral metabolism of lipoprotein-amyloid and neurovascular integrity.

该项目基于一项了不起的发现，该发现表明，在某些个体中，阿尔茨海默病可能是供应大脑的微观血管腐败的结果，由于血液中过度暴露于主要由肝脏产生的蛋白质而受损。该项目将在阿尔茨海默病高风险的受试者和人源化动物模型中进一步探索这一途径。这一发现可能为预防和治疗提供新的机会。

This project is based on a remarkable discovery which suggests that in some individuals, Alzheimer's disease may be a consequence of corruption of microscopic blood vessels that supply brain, damaged as a consequence of exaggerated exposure in blood to a protein produced principally in liver. The project will explore this pathway further in subjects at heightened risk of Alzheimer's disease and in humanised animal models. The findings may provide new opportunities for prevention and treatment.