Therapeutic targeting of MYCN oncoprotein stability in neuroblastoma

高水平的MYCN蛋白是侵袭性神经母细胞瘤(NB)的主要指标，但不幸的是，靶向治疗的设计存在许多障碍。我们已经确定了一种名为PA2G4的蛋白质，它是MYCN促进癌细胞生长的辅助因子。我们已经开发出一种化合物，可以抑制PA2G4和MYCN蛋白水平，并减少肿瘤生长。我们将研究PA2G4如何引起侵袭性肿瘤特征，并测试阻断PA2G4的新方法。

A high level of MYCN protein is a major indicator of aggressive neuroblastoma (NB) but unfortunately there have been many barriers to the design of targeted therapies. We have identified a protein called PA2G4 which is a cofactor for MYCN in promoting cancer cell growth. We have developed a compound which inhibits PA2G4 and MYCN protein levels and reduces tumour growth. We will examine how PA2G4 cause aggressive tumour characteristics and test new methods to block PA2G4.