Therapeutic Profiling of Atherosclerosis: Identifying and Testing Specific Targets in Plaque Instability

动脉粥样硬化的治疗分析：识别和测试斑块不稳定的特定目标

• 批准号: nhmrc : GNT1164921
• 金额: $ 90.59万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-profiling-atherosclerosis-plaque-instability/1379375
• 关键词: Therapeutic; Profiling; Atherosclerosis; Identifying; Testing

Heart attacks are the most frequent single cause of death. It is typically caused by rupture of atherosclerotic plaques and subsequent blockage of the arteries that supply the heart with blood. Advances towards the prevention of heart attacks have been hampered by the lack of an animal model, which we have recently developed and are planning to use to identify factors responsible for heart attacks. We also describe new drugs and nanoparticles that have the potential to prevent heart attacks.

心脏病发作是最常见的单一死因。它通常是由动脉粥样硬化斑块破裂和随后供应心脏血液的动脉堵塞引起的。由于缺乏动物模型，我们在预防心脏病发作方面的进展受到了阻碍，我们最近开发了动物模型，并计划利用该模型来确定导致心脏病发作的因素。我们还描述了有可能预防心脏病发作的新药和纳米颗粒。