Functional amalysis of Vc-Mrp and Vc-NhaP1, two non-canonical Na+/H+ antiporters in vibrio cholerae

霍乱弧菌中两种非典型 Na /H 逆向转运蛋白 Vc-Mrp 和 Vc-NhaP1 的功能分析

• 批准号: 227414-2009
• 负责人: Dibrov, Pavel
• 金额: $ 2.55万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=425130
• 关键词: Functional; amalysis; Vc; Mrp; NhaP1

Vibrio cholerae causes the often-fatal disease cholera, which has a long grim history and still affects many millions of people, mostly in the developing countries of Asia, Africa and Latin America. In this dangerous human pathogen, the circulation of sodium is intimately related to virulence. Therefore, investigation of sodium circulation in this bacterium is very important from both scientific and medical point of view. The sodium circulation in V. cholerae relies on specific proteins called Na+/H+ antiporters. These antiporters are usually single membrane proteins removing toxic sodium ions from the cell in exchange for external protons.

霍乱弧菌引起经常致命的疾病霍乱，它有着悠久的可怕历史，仍然影响着数百万人，大多数在亚洲、非洲和拉丁美洲的发展中国家。 在这种危险的人类病原体中，钠的循环与毒力密切相关。 因此，从科学和医学的角度来看，研究这种细菌中的钠循环是非常重要的。 霍乱弧菌中的钠循环依赖于称为Na+/H+反向转运蛋白的特定蛋白质。 这些反向转运蛋白通常是单膜蛋白，从细胞中去除有毒的钠离子，以换取外部质子。