Regulators mediating the proinflammatory cytokine response in uterine smooth muscle cells

介导子宫平滑肌细胞促炎细胞因子反应的调节因子

• 批准号: 238919-2008
• 负责人: Blank, Volker
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=425724
• 关键词: Regulators; mediating; proinflammatory; cytokine; response

The uterus plays a crucial role during human pregnancy and labor. We are studying the role of signaling molecules called cytokines in the regulation of uterine smooth muscle cells. We hypothesize that increased cytokine concentrations in the uterus due to bacterial infection lead to the premature onset of uterine contractions. We have used a genome-wide approach to identify novel cytokine regulated genes that are involved in the response of uterine smooth muscle cells to inflammatory stimuli. We will perform a detailed analysis of the identified candidate genes. These studies will help us to gain new insights into the molecular mechanisms involved in uterine cell function. Our research may lead to the design of novel diagnostic markers or treatments to prevent preterm labor.

子宫在人类怀孕和分娩过程中起着至关重要的作用。我们正在研究称为细胞因子的信号分子在子宫平滑肌细胞调节中的作用。我们推测，由于细菌感染导致子宫内细胞因子浓度增加导致子宫收缩过早发生。我们已经使用了全基因组的方法，以确定新的细胞因子调控的基因，参与子宫平滑肌细胞炎症刺激的反应。我们将对已确定的候选基因进行详细分析。这些研究将有助于我们对子宫细胞功能的分子机制有新的认识。我们的研究可能会导致新的诊断标记物或治疗方法的设计，以防止早产。