Regulators mediating the proinflammatory cytokine response in uterine smooth muscle cells

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The uterus plays a crucial role during human pregnancy and labor. We are studying the role of signaling molecules called cytokines in the regulation of uterine smooth muscle cells. We hypothesize that increased cytokine concentrations in the uterus due to bacterial infection lead to the premature onset of uterine contractions. We have used a genome-wide approach to identify novel cytokine regulated genes that are involved in the response of uterine smooth muscle cells to inflammatory stimuli. We will perform a detailed analysis of the identified candidate genes. These studies will help us to gain new insights into the molecular mechanisms involved in uterine cell function. Our research may lead to the design of novel diagnostic markers or treatments to prevent preterm labor.