Tissue specific T cells mediate drug hypersensitivity

组织特异性 T 细胞介导药物超敏反应

• 批准号: nhmrc : 1123499
• 负责人: A/Pr Alec Redwood
• 金额: $ 85.7万
• 依托单位: Murdoch University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-specific-t-drug-hypersensitivity/947185
• 关键词: Tissue; specific; cells; mediate; drug

T cells are immune cells that create dangerous and fatal drug allergies affecting the skin. An individual’s genetic makeup only partially explains predisposition to these reactions, we believe the missing link is contained in immune signatures specific to the skin. We aim to identify drug-specific T cells in the skin and develop a sensitive test to screen for rare, dangerous T cells in the blood. This will enable prediction and prevention of severe drug allergy and development of safer drugs.

T细胞是一种免疫细胞，它会产生影响皮肤的危险和致命的药物过敏。一个人的基因构成只能部分解释这些反应的易感性，我们认为缺失的环节包含在皮肤特有的免疫特征中。我们的目标是识别皮肤中的药物特异性T细胞，并开发一种敏感的测试来筛选血液中罕见的危险T细胞。这将有助于预测和预防严重的药物过敏，并开发更安全的药物。