Effects of natural sequence variation on evasion of cytotoxic T lymphocytes by murine cytomegalovirus.

自然序列变异对鼠巨细胞病毒逃避细胞毒性 T 淋巴细胞的影响。

• 批准号: nhmrc : 572574
• 负责人: A/Pr Alec Redwood
• 金额: $ 36.89万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-natural-sequence-murine-cytomegalovirus/82097
• 关键词: Effects; natural; sequence; variation; evasion

Human cytomegalovirus persists for the life time of an infected person. It has many ways of achieving this, including interfering with the host immune response. This project seeks to explore this using a mouse model and murine CMV. Specifically we will focus on a set of viral genes that inhibit host recognition of virally infected cells. Sequence variation in these genes suggests that they function differently in different strains of virus: we will examine the consequences of this variation.

人类巨细胞病毒在感染者的一生中持续存在。它有很多方法来达到这个目的，包括干扰宿主的免疫反应。本项目试图通过小鼠模型和小鼠巨细胞病毒来探索这一点。具体来说，我们将关注一组抑制宿主识别病毒感染细胞的病毒基因。这些基因的序列变异表明它们在不同病毒株中的功能不同：我们将研究这种变异的后果。