TRAFFICKING OF MEMBRANE SULFATE TRANSPORTERS IN THE KIDNEY

肾脏内硫酸膜转运蛋白的贩运

• 批准号: nhmrc : 143094
• 负责人: Prof Daniel Markovich
• 金额: $ 14.1万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trafficking-membrane-sulfate-transporters-kidney/94738
• 关键词: TRAFFICKING; MEMBRANE; SULFATE; TRANSPORTERS; KIDNEY

Many diseases such as diabetes, cystic fibrosis, Alzheimer's and Parkinson's, results from a defect in the intracellular trafficking of specific membrane proteins. One important family of membrane proteins are the renal sulphate transporters, NaSi-1 and sat-1. They are two important proteins that control body sulphate homeostasis. Sulphate in the body is essential for cell matrix formation and cartilage-bone development and growth. Trafficking defects in these proteins can lead to changes in serum sulphate levels, which results in softening of the bones, insufficient cartilage development, and changes in many metabolic processes. Using techniques of molecular and cellular biology, we aim to identify the precise the mechanisms that control the trafficking of these proteins in cells. This will enable us to determine how these proteins functions in both the normal and diseased states, which is currently unknown.

许多疾病，如糖尿病、囊性纤维化、阿尔茨海默氏症和帕金森氏症，都是由于特定膜蛋白在细胞内运输的缺陷造成的。一个重要的膜蛋白家族是肾脏硫酸盐转运蛋白，NASI-1和Sat-1。它们是控制体内硫酸盐稳态的两种重要蛋白质。体内的硫酸盐对细胞基质的形成和软骨-骨的发育和生长是必不可少的。这些蛋白质的运输缺陷会导致血清硫酸盐水平的变化，从而导致骨骼软化，软骨发育不足，以及许多代谢过程的改变。利用分子和细胞生物学技术，我们的目标是确定控制这些蛋白质在细胞内运输的精确机制。这将使我们能够确定这些蛋白质在正常和患病状态下的功能，这一点目前尚不清楚。