Cellular Ageing: Is the Plasma Membrane the Control Hub?

细胞衰老：质膜是控制中心吗？

• 批准号: DP240103193
• 负责人: Prof Jennifer Gamble
• 金额: $ 49.1万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103193
• 关键词: Cellular; Ageing; Plasma; Membrane; Control

This project aims to determine whether the plasma membrane lipid composition is a major driver of cellular ageing. It expects to generate new knowledge in the molecular mechanism of cellular ageing, utilising our team’s deep expertise in lipid biology, bioinformatics, biophysics, extracellular vesicle biology and cellular ageing. Expected outcomes include the identification of novel cellular ageing markers and anti-ageing targets while also cementing long-standing partnerships and fostering new interdisciplinary collaborations. This cellular ageing study will provide novel insights into the basic principles of cellular behaviour, e.g. growth, differentiation, communication and death, reinforcing Australia’s leadership in biological science.

该项目旨在确定质膜脂质成分是否是细胞衰老的主要驱动因素。它预计将产生新的知识在细胞衰老的分子机制，利用我们的团队在脂质生物学，生物信息学，生物物理学，细胞外囊泡生物学和细胞衰老的深厚专业知识。预期成果包括确定新的细胞衰老标志物和抗衰老目标，同时巩固长期伙伴关系并促进新的跨学科合作。这项细胞老化研究将为细胞行为的基本原理提供新的见解，例如生长、分化、交流和死亡，加强澳大利亚在生物科学方面的领导地位。