Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination
Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination
批准号:
nhmrc : 1027527
负责人:
A/Pr Alexander Dobrovic
金额:
$44.74万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
助长乳腺癌扩散的是逃逸到血液(CTC)和骨髓(DTC)中的小簇或单个癌细胞。由于提纯它们的难度很大,而且数量很少,因此无法对它们进行全面分析。使用两个新的、经过验证的小鼠模型来研究这些细胞,我们已经设计出一种方法,将在这些间隔中识别新的诊断和治疗靶点。这些最终将提供提高乳腺癌存活率的途径。
英文摘要
Fuelling the spread of breast cancer are small clusters or individual cancer cells that escape into the blood (CTC) and bone marrow (DTC). Comprehensive analysis of these is prohibited by difficulty in purifying them, and their small numbers. Using two novel, validated mouse models for these cells, we have devised an approach that will identify new diagnostic and therapeutic targets in these compartments. These will ultimately provide avenues to improve breast cancer survival.
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会议论文
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依托单位:
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Molecular profiling of sarcomas to enable clinical prediction and elucidate molecular pathogenesis
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财政年份:2005
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负责人:A/Pr Alexander Dobrovic
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依托单位:
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项目类别:NHMRC Project Grants
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资助金额:$37.41万
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财政年份:2005
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负责人:A/Pr Alexander Dobrovic
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依托单位:
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项目类别:NHMRC Project Grants
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财政年份:2000
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依托单位:
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依托单位:
国内基金
海外基金
高等植物远缘杂交诱导的表观遗传变异(epigenetic variation)现象及其在物种进化和新种形成中的作用
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批准号:30430060
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项目类别:重点项目
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资助金额:140.0万元
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批准年份:2004
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负责人:刘宝
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依托单位: