Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination

助长乳腺癌扩散的是逃逸到血液(CTC)和骨髓(DTC)中的小簇或单个癌细胞。由于提纯它们的难度很大，而且数量很少，因此无法对它们进行全面分析。使用两个新的、经过验证的小鼠模型来研究这些细胞，我们已经设计出一种方法，将在这些间隔中识别新的诊断和治疗靶点。这些最终将提供提高乳腺癌存活率的途径。

Fuelling the spread of breast cancer are small clusters or individual cancer cells that escape into the blood (CTC) and bone marrow (DTC). Comprehensive analysis of these is prohibited by difficulty in purifying them, and their small numbers. Using two novel, validated mouse models for these cells, we have devised an approach that will identify new diagnostic and therapeutic targets in these compartments. These will ultimately provide avenues to improve breast cancer survival.