Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination

乳腺癌播散中上皮间质可塑性的转录和表观遗传调控

• 批准号: nhmrc : 1027527
• 负责人: A/Pr Alexander Dobrovic
• 金额: $ 44.74万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-epigenetic-regulation-cancer-dissemination/110575
• 关键词: Transcriptional; Epigenetic; Regulation; Epithelial; Mesenchymal

Fuelling the spread of breast cancer are small clusters or individual cancer cells that escape into the blood (CTC) and bone marrow (DTC). Comprehensive analysis of these is prohibited by difficulty in purifying them, and their small numbers. Using two novel, validated mouse models for these cells, we have devised an approach that will identify new diagnostic and therapeutic targets in these compartments. These will ultimately provide avenues to improve breast cancer survival.

促进乳腺癌扩散的是逃逸到血液（CTC）和骨髓（DTC）中的小簇或单个癌细胞。由于难以净化它们，而且它们的数量很少，因此无法对它们进行全面分析。使用两种新的，经过验证的小鼠模型，这些细胞，我们已经设计了一种方法，将确定新的诊断和治疗目标，在这些隔室。这些最终将提供改善乳腺癌生存率的途径。