Transcriptional and Epigenetic Regulation of Epithelial Mesenchymal Plasticity in Breast Cancer Dissemination

逃逸到血液（CTC）和骨髓（DTC）中的小簇或单个癌细胞加速了乳腺癌的扩散。由于它们难以净化，而且数量少，因此无法对它们进行全面分析。利用两种新的、经过验证的小鼠模型，我们设计了一种方法，将在这些隔室中确定新的诊断和治疗靶点。这些最终将为提高乳腺癌患者的存活率提供途径。

Fuelling the spread of breast cancer are small clusters or individual cancer cells that escape into the blood (CTC) and bone marrow (DTC). Comprehensive analysis of these is prohibited by difficulty in purifying them, and their small numbers. Using two novel, validated mouse models for these cells, we have devised an approach that will identify new diagnostic and therapeutic targets in these compartments. These will ultimately provide avenues to improve breast cancer survival.