Transcriptional regulation of protective immunity

保护性免疫的转录调控

• 批准号: nhmrc : 1042092
• 负责人: Prof Gabrielle Belz
• 金额: $ 11.18万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-protective-immunity/111436
• 关键词: Transcriptional; regulation; protective; immunity

The development of protective immunity is essential to fight infection. This depends on a small number of master regulatory transcription factors that drive the differentiation of precursor cells into mature immune cells such as NK, T and dendritic cells. This proposal will provide a fundamental advance in our understanding of immune cells and impact strategies aimed at the prevention and treatment of pathogen infections.

保护性免疫的发展对对抗感染至关重要。这取决于少数主控调控转录因子，这些因子驱动前体细胞分化为成熟的免疫细胞，如NK细胞、T细胞和树突状细胞。这一建议将为我们对免疫细胞的理解和旨在预防和治疗病原体感染的影响策略提供一个根本性的进步。